Endocrine Abstracts

Introduction: In this present study, we assessed the effects of the last preoperative medical treatment (dopamine-agonists, somatostatin-analogous and GH receptor antagonists) on the proliferation parameters Ki-67 and Topoisomerase-IIα in pituitary adenomas of patients with acromegaly.Material and methods:: We retrospectively studied the clinical characteristics, neuroimaging, histology and immuno-histochemistry (Ki-67 and topoisomerase-IIα lab...

‘Silent’ ACTH-secreting pituitary adenomas are not characterized by specific clinical features that would suggest the presence of hypercortisolism. In contrast, they present as non-functioning pituitary macroadenomas with either visual compromise or hypercortisolism. However, immunostaining reveals ACTH-secreting cells.In order to characterize the laboratory features of these tumours, we have preoperatively assessed 56 patients with either clin...

The German Acrostudy is at present the largest database on acromegalics (n=184) treated with pegvisomant (Somavert®). 91% pts underwent pituitary surgery, 45% received radiation therapy, and previous medical therapy included dopamine agonists (56%), octreotide (90%) and/or lanreotide (10%). Common concomitant diseases at baseline were hypertension (47.0%), diabetes mellitus (31.7%), and gallstone disease (25.6%). Efficacy analysis was performed in 134 pt...